Complete plasmid sequence carrying type IV-like and type VII secretion systems from an atypical mycobacteria strain
نویسندگان
چکیده
The genus Mycobacterium is highly diverse and ubiquitous in nature, comprehending fast- and slow-growing species with distinct impact in public health. The plasmid-mediated horizontal gene transfer represents one of the major events in bacteria evolution. Here, we report the complete sequence of a 160,489 bp circular plasmid (pCBMA213_2) from an atypical and fast-growing environmental mycobacteria. This is a unique plasmid, in comparison with the characterised mycobacteria plasmids, harboring a type IV-like and ESX-P2 type VII secretion systems. pCBMA213_2 can be further explored for evolutionary and conjugation studies as well as a tool to manipulate DNA within this bacteria genus.
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متن کاملTitle: Evolutionary thrift: mycobacteria repurpose plasmid diversity during adaptation of type VII secretion systems Authors:
Mycobacteria have a distinct type of secretion system, termed type VII (T7SS), which is encoded by paralogous chromosomal loci (ESX) and associated with pathogenesis, conjugation, metal homeostasis and other functions. Gene duplication is an important mechanism by which novel gene functions can evolve. There are, however, potential conflicts between adaptive forces that stabilize duplicated gen...
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Mycobacteria have a distinct secretion system, termed type VII (T7SS), which is encoded by paralogous chromosomal loci (ESX) and associated with pathogenesis, conjugation, and metal homeostasis. Evolution of paralogous gene families is of interest because duplication is an important mechanism by which novel genes evolve, but there are potential conflicts between adaptive forces that stabilize d...
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